JAK2 participates in the insulin-stimulated mitogenic pathway. Diabetologia (1997) 40: S25–S31 Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor D. Ish-Shalom1, C.T. In addition to its prominent metabolic action, insulin has a well-known mitogenic effect, promoting proliferation in … Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased … Moreover, TSH potentiated the mitogenic effect of insulin only in low density cultures. Either endogenous or exogenous hyperinsulinaemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras proteins. All of our epithelial ovarian cancer cell lines except OV202, which had the lowest specific insulin binding, responded to low levels of insulin …

It is unclear whether insulin may have a direct or indirect effect on the lamellar tissues.

In addition to its typical metabolic effects, insulin is also a growth factor as shown by both in vitro and in vivo evidence. Liefvendahl, E. & Arnqvist, H. J. Mitogenic effect of the insulin analogue glargine in malignant cells in comparison with insulin and IGF-I. We have investigated the mitogenic effect of three mutant forms of human insulin on insulin-producing beta cells of the developing pancreas. Insulin mitogenic effect was first believed to occur only at high concentrations via the IGF-1 receptor (IGF-1R), but it was later demonstrated to occur also at lower concentrations via its own receptor (Ish-Shalom et al., 1997). Our study supports the second hypothesis that insulin receptors on epithelial ovarian cancer cells mediate a mitogenic effect of insulin. In contrast to TSH, FCS induced a similar proliferative response at both high and low cell density. Insulin is a powerful mitogen and when insulin levels are increased because of insulin-resitance its activity can spill over onto IGF-1 receptors. the mitogenic effects of both growth factors [6].) Christoffersen2, P. Vorwerk2, N. Sacerdoti-Sierra1, R.M. Shymko2,D.Naor1, P. De Meyts2 It is possible that JAK2 exerts some positive contribution on IRS-1 tyrosyl phosphorylation that obscures detection of the improved effect of insulin receptor–dependent phosphorylation. Introduction. Effects of diverse stimuli, including insulin, muscle contraction, and phorbol 12-myristate-13-acetate (PMA), were determined on phosphorylation of mitogen-activated protein kinase (MAPK) signaling modules (c-Jun NH2-terminal kinase [JNK], p38 MAPK, and extracellular signal-related kinase [ERK1/2]) in skeletal muscle from lean and ob/ob mice. Background In horses and ponies, insulin dysregulation leading to hyperinsulinemia may be associated with increased risk of laminitis, and prolonged infusion of insulin can induce the condition. Following TSH stimulation, cAMP content was always increased, paralleling the effect of growth in low density but not in high density cultures.

Insulin as a Growth Factor Favoring Cancer Development.

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